- Abstract:
-
Goto-Kakizaki (GK) rats are a well characterized model for non-insulin dependent diabetes mellitus (NIDDM). We have used a combination of physiological and genetic studies to identify quantitative trait loci (QTLs) responsible for the control of glucose homeostasis and insulin secretion in a F2 cohort bred from spontaneously diabetic GK rats. The genetic dissection of NIDDM allowed us to map up to six independently segregating loci predisposing to hyperglycaemia, glucose intolerance or altere...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/ng0196-38
-
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- Journal:
- Nature genetics
- Volume:
- 12
- Issue:
- 1
- Pages:
- 38-43
- Publication date:
- 1996-01-05
- DOI:
- EISSN:
-
1546-1718
- ISSN:
-
1061-4036
- URN:
-
uuid:4d8abbc0-4655-47f6-a0af-a6d48b8d824a
- Source identifiers:
-
7695
- Local pid:
- pubs:7695
- Copyright date:
- 1996
Journal article
Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat.
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