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Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat.

Abstract:

Goto-Kakizaki (GK) rats are a well characterized model for non-insulin dependent diabetes mellitus (NIDDM). We have used a combination of physiological and genetic studies to identify quantitative trait loci (QTLs) responsible for the control of glucose homeostasis and insulin secretion in a F2 cohort bred from spontaneously diabetic GK rats. The genetic dissection of NIDDM allowed us to map up to six independently segregating loci predisposing to hyperglycaemia, glucose intolerance or altere...

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Publication status:
Published

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Publisher copy:
10.1038/ng0196-38

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Role:
Author
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Journal:
Nature genetics
Volume:
12
Issue:
1
Pages:
38-43
Publication date:
1996-01-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:4d8abbc0-4655-47f6-a0af-a6d48b8d824a
Source identifiers:
7695
Local pid:
pubs:7695

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