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Inferring malaria parasite population structure from serological networks

Abstract:

The malaria parasite Plasmodium falciparum is characterized by high levels of genetic diversity at antigenic loci involved in virulence and immune evasion. Knowledge of the population structure and dynamics of these genes is important for designing control programmes and understanding the acquisition of immunity to malaria; however, high rates of homologous and non-homologous recombination as well as complex patterns of expression within hosts have hindered attempts to elucidate thes...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1098/rspb.2008.1122

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Institution:
"University of Oxford", "Wellcome Collaborative Research Program, KEMRI, Kilifi, Kenya", "Santa Fe Institute, Santa Fe, NM, USA"
Department:
Mathematical,Physical & Life Sciences Division - Zoology
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Institution:
"Wellcome Collaborative Research Program, KEMRI, Kilifi, Kenya", "University of Oxford"
Department:
Medical Sciences Division - Clinical Vaccinology and Tropical Medicine,Centre for (CCVTM)
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Institution:
University of Oxford
Department:
Mathematical,Physical & Life Sciences Division - Zoology
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Funding agency for:
Caroline O. Buckee
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Funding agency for:
Peter C. Bull
Publisher:
Royal Society Publishing Publisher's website
Journal:
Proceedings of the Royal Society B: Biological Sciences Journal website
Volume:
276
Issue:
1656
Pages:
477-485
Publication date:
2009-02-05
DOI:
EISSN:
1471-2954
URN:
uuid:4d800c55-8875-4f52-9caa-fbe5e2431560
Local pid:
ora:3629

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