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Computational approach for determining the spectrum of DNA damage induced by ionizing radiation.

Abstract:

To study the characteristics of molecular damage induced by ionizing radiation at the DNA level, Monte Carlo track simulation of energetic electrons and ions in liquid water, a canonical model of B-DNA, and a comprehensive classification of DNA damage in terms of the origin and complexity of damage were used to calculate the frequencies of simple and complex strand breaks. A threshold energy of 17.5 eV was used to model the damage by direct energy deposition, and a probability of 0.13 was app...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Wilson, WE More by this author
Goodhead, DT More by this author
Journal:
Radiation research
Volume:
156
Issue:
5 Pt 2
Pages:
577-583
Publication date:
2001-11-05
DOI:
EISSN:
1938-5404
ISSN:
0033-7587
URN:
uuid:4d7f70a2-474b-4d8f-80e5-0d0db1f5630b
Source identifiers:
131243
Local pid:
pubs:131243

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