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Ex vivo depletion of T cells from bone marrow grafts with CAMPATH-1 in acute leukemia: graft-versus-host disease and graft-versus-leukemia effect.

Abstract:

BACKGROUND: Preventing graft-versus-host disease (GVHD) by depletion of T lymphocytes from the stem cell graft for transplantation remains controversial, mainly because of the perceived increase in disease recurrence. METHODS: We retrospectively analyzed the outcome of 50 consecutive individuals in remission of acute lymphoblastic leukemia (n=13; 8 in complete remission [CR]1) or acute myeloblastic leukemia (n=37; 33 in CR1), who had received marrow grafts from HLA-identical siblings. The con...

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Publication status:
Published

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Authors


Novitzky, N More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Transplantation
Volume:
67
Issue:
4
Pages:
620-626
Publication date:
1999-02-05
DOI:
EISSN:
1534-6080
ISSN:
0041-1337
URN:
uuid:4d714c6f-0172-41cf-98a7-4a665801bb9d
Source identifiers:
762
Local pid:
pubs:762

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