- Abstract:
-
Clinical manifestations of Plasmodium falciparum infection are induced by the asexual stages of the parasite that develop inside red blood cells (RBCs). Because splenic microcirculatory beds filter out altered RBCs, the spleen can innately clear subpopulations of infected or uninfected RBC modified during falciparum malaria. The spleen appears more protective against severe manifestations of malaria in naïve than in immune subjects. The spleen-specific pitting function accounts for a large fr...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1182/blood-2010-04-202911
-
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- Journal:
- Blood
- Volume:
- 117
- Issue:
- 2
- Pages:
- 381-392
- Publication date:
- 2011-01-05
- DOI:
- EISSN:
-
1528-0020
- ISSN:
-
0006-4971
- URN:
-
uuid:4d6aaf48-2aa4-4356-859b-00be99e6461d
- Source identifiers:
-
177202
- Local pid:
- pubs:177202
- Language:
- English
- Keywords:
- Copyright date:
- 2011
Journal article
The pathogenesis of Plasmodium falciparum malaria in humans: insights from splenic physiology.
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