Clinical manifestations of Plasmodium falciparum infection are induced by the asexual stages of the parasite that develop inside red blood cells (RBCs). Because splenic microcirculatory beds filter out altered RBCs, the spleen can innately clear subpopulations of infected or uninfected RBC modified during falciparum malaria. The spleen appears more protective against severe manifestations of malaria in naïve than in immune subjects. The spleen-specific pitting function accounts for a large fr...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
The pathogenesis of Plasmodium falciparum malaria in humans: insights from splenic physiology.
Views and Downloads
If you are the owner of this record, you can report an update to it here: Report update to this record