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Journal article

The pathogenesis of Plasmodium falciparum malaria in humans: insights from splenic physiology.

Abstract:

Clinical manifestations of Plasmodium falciparum infection are induced by the asexual stages of the parasite that develop inside red blood cells (RBCs). Because splenic microcirculatory beds filter out altered RBCs, the spleen can innately clear subpopulations of infected or uninfected RBC modified during falciparum malaria. The spleen appears more protective against severe manifestations of malaria in naïve than in immune subjects. The spleen-specific pitting function accounts for a large fr...

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Publication status:
Published

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Journal:
Blood
Volume:
117
Issue:
2
Pages:
381-392
Publication date:
2011-01-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:4d6aaf48-2aa4-4356-859b-00be99e6461d
Source identifiers:
177202
Local pid:
pubs:177202

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