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Reduction in subthalamic 8-35 Hz oscillatory activity correlates with clinical improvement in Parkinson's disease.

Abstract:

Strong synchronization of neuronal activity occurs in the 8-35 Hz band in the subthalamic nucleus (STN) of patients with Parkinson's disease (PD) and is evident as oscillatory local field potential (LFP) activity. To test whether such synchronization may contribute to bradykinesia and rigidity, we sought correlations between the suppression of synchronization at 8-35 Hz in STN and the reduction in Parkinsonism with levodopa. LFPs were recorded on and off medication from STN deep-brain stimula...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, Biomedical Research Centre
Role:
Author
Journal:
The European journal of neuroscience
Volume:
23
Issue:
7
Pages:
1956-1960
Publication date:
2006-04-05
DOI:
EISSN:
1460-9568
ISSN:
0953-816X
URN:
uuid:4d6a72f4-035b-4324-8df4-b8dff065bc48
Source identifiers:
70887
Local pid:
pubs:70887

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