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Strong heterogeneity in mutation rate causes misleading hallmarks of natural selection on indel mutations in the human genome

Abstract:

Elucidating the mechanisms of mutation accumulation and fixation is critical to understand the nature of genetic variation and its contribution to genome evolution. Of particular interest is the effect of insertions and deletions (indels) on the evolution of genome landscapes. Recent population-scaled sequencing efforts provide unprecedented data for analyzing the relative impact of selection versus nonadaptive forces operating on indels. Here, we combined McDonald–Kreitman tests with the ana...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/molbev/mst185

Authors


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Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Wellcome Trust Centre for Human Genetics
More by this author
Institution:
Université Lyon
Publisher:
Oxford University Press Publisher's website
Journal:
Molecular Biology and Evolution Journal website
Volume:
31
Issue:
1
Pages:
23–36
Publication date:
2013-10-05
DOI:
EISSN:
1537-1719
ISSN:
0737-4038
URN:
uuid:4d515e61-bce9-4a78-ac80-45234c853fb9
Local pid:
ora:8057

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