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G protein-dependent inhibition of L-type Ca2+ currents by acetylcholine in mouse pancreatic B-cells.

Abstract:

1. The effect of acetylcholine (ACh) on voltage-dependent Ca2+ currents in mouse pancreatic B-cells was studied using the whole-cell configuration of the patch-clamp technique. 2. ACh (0.25-250 microM) reversibly and dose-dependently inhibited the Ca2+ current elicited by depolarizations from -80 mV to +10 mV. Maximal inhibition was observed at concentrations > 25 microM where it amounted to approximately 35%. The effect was voltage independent and prevented by atropine (10 microM) suggest...

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Publication status:
Published

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Journal:
The Journal of physiology
Volume:
499 ( Pt 1)
Issue:
1
Pages:
65-76
Publication date:
1997-02-05
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:4d3d9c23-b154-4c7a-8926-c11b68c238c1
Source identifiers:
7917
Local pid:
pubs:7917

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