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Cerebrospinal fluid corticosteroid levels and cortisol metabolism in patients with idiopathic intracranial hypertension: a link between 11beta-HSD1 and intracranial pressure regulation?

Abstract:

CONTEXT: The etiology of idiopathic intracranial hypertension (IIH) is unknown. We hypothesized that obesity and elevated intracranial pressure may be linked through increased 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activity. OBJECTIVE: The aim was to characterize 11β-HSD1 in human cerebrospinal fluid (CSF) secretory [choroid plexus (CP)] and drainage [arachnoid granulation tissue (AGT)] structures, and to evaluate 11β-HSD1 activity after therapeutic weight loss in IIH. DESIGN AND ...

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Publication status:
Published

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Publisher copy:
10.1210/jc.2010-0729

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Journal:
The Journal of clinical endocrinology and metabolism
Volume:
95
Issue:
12
Pages:
5348-5356
Publication date:
2010-12-05
DOI:
EISSN:
1945-7197
ISSN:
0021-972X
URN:
uuid:4d3bdb11-40db-40b9-a923-b1034489c725
Source identifiers:
482076
Local pid:
pubs:482076

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