Journal article
Cerebrospinal fluid corticosteroid levels and cortisol metabolism in patients with idiopathic intracranial hypertension: a link between 11beta-HSD1 and intracranial pressure regulation?
- Abstract:
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CONTEXT: The etiology of idiopathic intracranial hypertension (IIH) is unknown. We hypothesized that obesity and elevated intracranial pressure may be linked through increased 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activity. OBJECTIVE: The aim was to characterize 11β-HSD1 in human cerebrospinal fluid (CSF) secretory [choroid plexus (CP)] and drainage [arachnoid granulation tissue (AGT)] structures, and to evaluate 11β-HSD1 activity after therapeutic weight loss in IIH. DESIGN AND ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1210/jc.2010-0729
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Bibliographic Details
- Journal:
- Journal of clinical endocrinology and metabolism
- Volume:
- 95
- Issue:
- 12
- Pages:
- 5348-5356
- Publication date:
- 2010-12-01
- DOI:
- EISSN:
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1945-7197
- ISSN:
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0021-972X
- Source identifiers:
-
482076
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:482076
- UUID:
-
uuid:4d3bdb11-40db-40b9-a923-b1034489c725
- Local pid:
- pubs:482076
- Deposit date:
- 2014-08-29
Terms of use
- Copyright date:
- 2010
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