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Molecular flexibility of DNA as a major determinant of RAD51 recruitment

Abstract:

The timely activation of homologous recombination (HR) is essential for the maintenance of genome stability, in which the RAD51 recombinase plays a central role. In vivo, RAD51 polymerises on single-stranded DNA (ssDNA) at double-strand breaks (DSBs) to catalyse HR-dependent DSB repair. Biochemically, human RAD51 polymerises faster on ssDNA compared to double-stranded DNA (dsDNA), raising a key conceptual question: how does it discriminate between them? Throughout this thesis, I ...

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Department:
Sir William Dunn School of Pathology, University of Oxford

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Role:
Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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