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Recapitulation of Werner syndrome sensitivity to camptothecin by limited knockdown of the WRN helicase/exonuclease

Abstract:

WRN is a RecQ helicase with an associated exonuclease activity important in DNA metabolism, including DNA replication, repair and recombination. In humans, deficiencies in WRN function cause the segmental progeroid Werner syndrome (WS), in which patients show premature onset of many hallmarks of normal human ageing. At the cellular level, WRN loss results in rapid replicative senescence, chromosomal instability and sensitivity to various DNA damaging agents including the topoisomerase inhibit...

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Publisher copy:
10.1007/s10522-011-9341-8

Authors


Jennert-Burston, KCB More by this author
Bachler, MA More by this author
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Journal:
Biogerontology
Volume:
13
Issue:
1
Pages:
49-62
Publication date:
2012-02-05
DOI:
EISSN:
1573-6768
ISSN:
1389-5729
URN:
uuid:4d3a43f5-adac-4369-86c7-0f88cfe66d6c
Source identifiers:
321573
Local pid:
pubs:321573

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