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An introduction to genes, genomes and disease.

Abstract:

The human and other genome projects and subsequent resequencing programmes have provided new perspectives on the nature of the gene and how genes function. Understanding the complexity of the eukaryotic nucleus and the diversity of genetic regulatory mechanisms, including the role of non-coding RNAs, translational control mechanisms and the extraordinary prevalence of splicing, will be central to understanding how genes function, as will the recognition of gene dosage issues. This introductio...

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Publication status:
Published

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Publisher copy:
10.1002/path.2652

Authors


Reis-Filho, JS More by this author
Tomlinson, IP More by this author
Poulsom, R More by this author
Journal:
The Journal of pathology
Volume:
220
Issue:
2
Pages:
109-113
Publication date:
2010-01-05
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
URN:
uuid:4d36fd22-4e50-4147-bf47-5844e5bdc706
Source identifiers:
72282
Local pid:
pubs:72282

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