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Inhibition of hypoxia-inducible factor-targeting prolyl hydroxylase domain-containing protein 2 (PHD2) enhances matrix synthesis by human chondrocytes.

Abstract:

Human articular cartilage is an avascular tissue, and therefore it functions in a hypoxic environment. Cartilage cells, the chondrocytes, have adapted to this and actually use hypoxia to drive tissue-specific functions. We have previously shown that human chondrocytes enhance cartilage matrix synthesis in response to hypoxia specifically through hypoxia-inducible factor 2alpha (HIF-2alpha)-mediated up-regulation of master regulator transcription factor SOX9, which in turn drives expression of...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m110.115238

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
The Journal of biological chemistry
Volume:
285
Issue:
27
Pages:
20472-20480
Publication date:
2010-07-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:4d35884f-93c4-4107-8e70-3fdc8202da7c
Source identifiers:
226500
Local pid:
pubs:226500

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