Psychophysical and functional imaging evidence supporting the presence of central sensitization in a cohort of osteoarthritis patients.

Journal article

OBJECTIVE: The groin pain experienced by patients with hip osteoarthritis (OA) is often accompanied by areas of referred pain and changes in skin sensitivity. We aimed to identify the supraspinal influences that underlie these clinical manifestations that we consider indicative of possible central sensitization. METHODS: Twenty patients with hip OA awaiting joint replacement and displaying signs of referred pain were recruited into the study, together with age-matched controls. All subjects c...

Expand abstract

Authors: Gwilym, S; Keltner, JR; Warnaby, C; Carr, A; Chizh, B

• Publication status: Published
• Journal: Arthritis and rheumatism
• Volume: 61
• Issue: 9
• Pages: 1226-1234
• Publication date: 2009-09-01
• DOI: 10.1002/art.24837
• EISSN: 1529-0131
• ISSN: 0004-3591
• Language: English
• Keywords: Brain; Magnetic Resonance Imaging; Female; Pressure; Cohort Studies; Skin; Nociceptors; Evoked Potentials, Somatosensory; Central Nervous System; Male; Aged; Osteoarthritis, Hip; Case-Control Studies; Health Surveys; Pain; Middle Aged; Cold Temperature; Humans