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Low affinity of cell surface lymphocyte function-associated antigen-1 (LFA-1) generates selectivity for cell-cell interactions.

Abstract:

We examined binding of soluble intercellular adhesion molecule-1 (ICAM-1) dimers and a range of ICAM-1-coated particles to activated T cells. Lymphocyte function-associated antigen-1 (LFA-1) on the surface of activated T cells did not bind soluble ICAM-1 dimers with high affinity. In contrast, activated T cells adhered avidly to ICAM-1-coated planar surfaces. Between these two extremes, a range of ICAM-1-bearing particles was tested for binding. Activated T cells bound particles of 1-microm d...

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
159
Issue:
6
Pages:
2685-2692
Publication date:
1997-09-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:4d2fed34-afab-40ce-9599-098f6b0ed6cc
Source identifiers:
482675
Local pid:
pubs:482675

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