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DNA polymerase delta-dependent repair of DNA single strand breaks containing 3'-end proximal lesions.

Abstract:

Base excision repair (BER) is the major pathway for the repair of simple, non-bulky lesions in DNA that is initiated by a damage-specific DNA glycosylase. Several human DNA glycosylases exist that efficiently excise numerous types of lesions, although the close proximity of a single strand break (SSB) to a DNA adduct can have a profound effect on both BER and SSB repair. We recently reported that DNA lesions located as a second nucleotide 5'-upstream to a DNA SSB are resistant to DNA glycosyl...

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Publication status:
Published

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Publisher copy:
10.1093/nar/gkl1115

Authors


Parsons, JL More by this author
Preston, BD More by this author
O'Connor, TR More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Journal:
Nucleic acids research
Volume:
35
Issue:
4
Pages:
1054-1063
Publication date:
2007
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:4d153164-e9d8-479c-adf6-3e36b1c81b16
Source identifiers:
131160
Local pid:
pubs:131160

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