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Journal article

ETO/MTG8 is an inhibitor of C/EBPbeta activity and a regulator of early adipogenesis.

Abstract:

The putative transcriptional corepressor ETO/MTG8 has been extensively studied due to its involvement in a chromosomal translocation causing the t(8;21) form of acute myeloid leukemia. Despite this, the role of ETO in normal physiology has remained obscure. Here we show that ETO is highly expressed in preadipocytes and acts as an inhibitor of C/EBPbeta during early adipogenesis, contributing to its characteristically delayed activation. ETO prevents both the transcriptional activation of the ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
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Journal:
Molecular and cellular biology
Volume:
24
Issue:
22
Pages:
9863-9872
Publication date:
2004-11-05
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
URN:
uuid:4d14b00d-7dcf-4aa9-b5da-6fbaad1eabcd
Source identifiers:
149973
Local pid:
pubs:149973

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