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Adenosine stress CMR T1-mapping detects early microvascular dysfunction in patients with type 2 diabetes mellitus without obstructive coronary artery disease

Abstract:

Background: Type 2 diabetes mellitus (T2DM) is associated with coronary microvascular dysfunction in the absence of obstructive coronary artery disease (CAD). Cardiovascular magnetic resonance (CMR) T1-mapping at rest and during adenosine stress can assess coronary vascular reactivity. We hypothesised that the non-contrast T1 response to vasodilator stress will be altered in patients with T2DM without CAD compared to controls due to coronary microvascular dysfunction.

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
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Publisher copy:
10.1186/s12968-017-0397-8

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
Role:
Author
ORCID:
0000-0002-3799-7102
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
Role:
Author
ORCID:
0000-0002-8261-8343
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
Role:
Author
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National Institute for Health Research Biomedical Research Centre Programme More from this funder
Oxford British Heart Foundation Centre for Research Excellence More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
Journal of Cardiovascular Magnetic Resonance Journal website
Volume:
19
Issue:
1
Pages:
81
Publication date:
2017-10-25
Acceptance date:
2017-10-12
DOI:
EISSN:
1532-429X
ISSN:
1097-6647
Pubs id:
pubs:739145
URN:
uri:4d0df633-2a62-4a29-9189-0dd3f516db42
UUID:
uuid:4d0df633-2a62-4a29-9189-0dd3f516db42
Local pid:
pubs:739145
Paper number:
ARTN 81

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