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The small chromosomes of Trypanosoma brucei involved in antigenic variation are constructed around repetitive palindromes.

Abstract:

Most eukaryotic genomes contain large regions of satellite DNA. These arrays are often associated with essential chromosomal functions, but remain largely absent from genome projects because of difficulties in cloning and sequence assembly. The numerous small chromosomes of the parasite Trypanosoma brucei fall into this category, yet are critical to understanding the genome because of their role in antigenic variation. Their relatively small size, however, makes them particularly amenable to ...

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Publication status:
Published

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Publisher copy:
10.1101/gr.2227704

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Genome research
Volume:
14
Issue:
6
Pages:
1014-1024
Publication date:
2004-06-05
DOI:
EISSN:
1549-5469
ISSN:
1088-9051
URN:
uuid:4d0ad2f1-874d-4024-aec1-035fda47d47b
Source identifiers:
16867
Local pid:
pubs:16867

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