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Genetic analysis of primaquine tolerance in a patient with relapsing vivax malaria.

Abstract:
Patients with Plasmodium vivax malaria are treated with primaquine to prevent relapse infections. We report primaquine failure in a patient with 3 relapses without any possibility of re-infection. Using whole genome sequencing of the relapsing parasite isolates, we identified single nucleotide variants as candidate molecular markers of resistance.
Publication status:
Published

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Publisher copy:
10.3201/eid1905.121852

Authors


Bright, AT More by this author
Alenazi, T More by this author
Shokoples, S More by this author
Tarning, J More by this author
Paganotti, GM More by this author
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Journal:
Emerging infectious diseases
Volume:
19
Issue:
5
Pages:
802-805
Publication date:
2013-05-05
DOI:
EISSN:
1080-6059
ISSN:
1080-6040
URN:
uuid:4cf451a1-903e-44c5-bdf9-c66709fcac9b
Source identifiers:
405846
Local pid:
pubs:405846

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