Genetic analysis of primaquine tolerance in a patient with relapsing vivax malaria.
- Patients with Plasmodium vivax malaria are treated with primaquine to prevent relapse infections. We report primaquine failure in a patient with 3 relapses without any possibility of re-infection. Using whole genome sequencing of the relapsing parasite isolates, we identified single nucleotide variants as candidate molecular markers of resistance.
- Publication status:
- Publisher copy:
- Copyright date: