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Route of monocyte differentiation determines their cytokine production profile: CD40 ligation induces interleukin 10 expression.

Abstract:

Interleukin 10 is a potent anti-inflammatory and immunomodulatory cytokine. Little is known regarding its induction in monocytes/macrophages, however LPS, a reproducible trigger of IL-10, is augmented by direct contact with T cells. In this context, the role of CD40-ligation is investigated. In the rheumatoid synovium, IL-10 is produced by tissue macrophages. Monocytes primed with M-CSF, a cytokine present in rheumatoid joints, produced IL-1beta, TNF-alpha and IL-10 upon CD40-ligation at an I...

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Publication status:
Published

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Publisher copy:
10.1006/cyto.2000.0750

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Cytokine
Volume:
12
Issue:
10
Pages:
1496-1505
Publication date:
2000-10-01
DOI:
EISSN:
1096-0023
ISSN:
1043-4666
Source identifiers:
224778

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