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Variants in ST8SIA1 do not play a major role in susceptibility to multiple sclerosis in Canadian families.

Abstract:

Multiple sclerosis (MS) is a complex trait with a significant genetic component. Recent work has implicated the ST8SIA1 gene, encoding a ganglioside synthase, in susceptibility to the disease, perhaps with a parent-of-origin effect. In this investigation of 1318 MS patients from 756 Canadian families, we analysed the transmission of the four single nucleotide polymorphisms in ST8SIA previously shown to be associated with MS. No significant association was found in the entire sample or when st...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Morrison, KM More by this author
Disanto, G More by this author
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Journal:
Journal of neuroimmunology
Volume:
212
Issue:
1-2
Pages:
142-144
Publication date:
2009-07-05
DOI:
EISSN:
1872-8421
ISSN:
0165-5728
URN:
uuid:4c7fee71-6e69-4047-8bd4-0130b212b308
Source identifiers:
34714
Local pid:
pubs:34714

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