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Structural basis for LMO2-driven recruitment of the SCL:E47bHLH heterodimer to hematopoietic-specific transcriptional targets.

Abstract:

Cell fate is governed by combinatorial actions of transcriptional regulators assembling into multiprotein complexes. However, the molecular details of how these complexes form are poorly understood. One such complex, which contains the basic-helix-loop-helix heterodimer SCL:E47 and bridging proteins LMO2:LDB1, critically regulates hematopoiesis and induces T cell leukemia. Here, we report the crystal structure of (SCL:E47)bHLH:LMO2:LDB1LID bound to DNA, providing a molecular account of the ne...

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Publication status:
Published

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Journal:
Cell reports
Volume:
4
Issue:
1
Pages:
135-147
Publication date:
2013-07-01
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Source identifiers:
410920

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