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Effects of temporarily suspending low-dose methotrexate treatment for 2 weeks after SARS-CoV-2 vaccine booster on vaccine response in immunosuppressed adults with inflammatory conditions: protocol for a multicentre randomised controlled trial and nested mechanistic substudy (Vaccine Response On/Off Methotrexate (VROOM) study)

Abstract:
Introduction It is unknown if a temporary break in long-term immune-suppressive treatment after vaccination against COVID-19 improves vaccine response. The objective of this study was to evaluate if a 2-week interruption in low-dose weekly methotrexate treatment after SARS-CoV-2 vaccine boosters enhances the immune response compared with continuing treatment in adults with autoimmune inflammatory conditions.
Methods and analysis An open-label, pragmatic,... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1136/bmjopen-2022-062599

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Botnar Research Centre
Oxford college:
St Hugh's College
Role:
Author
ORCID:
0000-0001-9631-3666
Publisher:
BMJ Publishing Group Publisher's website
Journal:
BMJ Open Journal website
Volume:
112
Issue:
5
Article number:
e06259
Publication date:
2022-05-03
Acceptance date:
2022-03-18
DOI:
EISSN:
2044-6055
Language:
English
Keywords:
Pubs id:
1246336
Local pid:
pubs:1246336
Deposit date:
2022-03-18

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