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Bone marrow-derived cells do not contribute significantly to collagen I synthesis in a murine model of renal fibrosis.

Abstract:

Interstitial fibroblasts play a central role in kidney fibrosis. Their origin is debated, with recent data indicating a contribution of bone marrow (BM)-derived cells to the expanded population of interstitial cells after kidney damage in animals and humans. This study investigated whether these BM-derived cells would respond appropriately to a fibrotic drive by producing collagen. A transgenic mouse that expresses both luciferase and beta-galactosidase reporter molecules under the control of...

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Publication status:
Published

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Publisher copy:
10.1681/asn.2005080795

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Journal of the American Society of Nephrology : JASN
Volume:
17
Issue:
3
Pages:
775-782
Publication date:
2006-03-01
DOI:
EISSN:
1533-3450
ISSN:
1046-6673
Source identifiers:
223505

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