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Phenol derivatives accelerate inactivation kinetics in one inactivation-deficient mutant human skeletal muscle Na(+) channel.

Abstract:

Altered inactivation kinetics in skeletal muscle Na(+) channels due to mutations in the encoding gene are causal for the alterations in muscle excitability in nondystrophic myotonia. Na(+) channel blockers like lidocaine and mexiletine, suggested for therapy of myotonia, do not reconstitute inactivation in channels with defective inactivation in vitro. We examined the effects of four methylated and/or halogenated phenol derivatives on one heterologously expressed inactivation-deficient Paramy...

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Publication status:
Published

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Journal:
European journal of pharmacology
Volume:
416
Issue:
1-2
Pages:
11-18
Publication date:
2001-03-05
DOI:
EISSN:
1879-0712
ISSN:
0014-2999
URN:
uuid:4c71b97b-a541-4090-9601-aa1e9a16c30f
Source identifiers:
322131
Local pid:
pubs:322131

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