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Bayesian inference of agent-based models: a tool for studying kidney branching morphogenesis

Abstract:

The adult mammalian kidney has a complex, highly-branched collecting duct epithelium that arises as a ureteric bud sidebranch from an epithelial tube known as the nephric duct. Subsequent branching of the ureteric bud to form the collecting duct tree is regulated by subcellular interactions between the epithelium and a population of mesenchymal cells that surround the tips of outgrowing branches. The mesenchymal cells produce glial cell-line derived neurotrophic factor (GDNF), that binds with...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1007/s00285-018-1208-z

Authors


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Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
ORCID:
0000-0003-4274-4158
MacLean, AL More by this author
Fletcher, AG More by this author
Combes, AN More by this author
Little, MH More by this author
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Publisher:
Springer Publisher's website
Journal:
Journal of Mathematical Biology Journal website
Volume:
76
Issue:
7
Pages:
1673-1697
Publication date:
2018-02-01
Acceptance date:
2018-01-02
DOI:
EISSN:
1432-1416
ISSN:
0303-6812
Pubs id:
pubs:823188
URN:
uri:4c6c8698-7b78-4b43-8736-507009faef1d
UUID:
uuid:4c6c8698-7b78-4b43-8736-507009faef1d
Local pid:
pubs:823188

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