- Abstract:
-
DNA ligases finalize DNA replication and repair through DNA nick-sealing reactions that can abort to generate cytotoxic 5'-adenylation DNA damage. Aprataxin (Aptx) catalyzes direct reversal of 5'-adenylate adducts to protect genome integrity. Here the structure of a Schizosaccharomyces pombe Aptx-DNA-AMP-Zn(2+) complex reveals active site and DNA interaction clefts formed by fusing a histidine triad (HIT) nucleotide hydrolase with a DNA minor groove-binding C(2)HE zinc finger (Znf). An Aptx h...
Expand abstract - Publisher copy:
- 10.1038/nsmb.2146
-
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- Journal:
- Nature structural and molecular biology
- Volume:
- 18
- Issue:
- 11
- Pages:
- 1189-1195
- Publication date:
- 2011-11-05
- DOI:
- EISSN:
-
1545-9985
- ISSN:
-
1545-9993
- URN:
-
uuid:4c6afcd9-6ac9-4183-9881-bdd9f63a4c85
- Source identifiers:
-
376194
- Local pid:
- pubs:376194
- Language:
- English
- Keywords:
- Copyright date:
- 2011
Journal article
Structure of an aprataxin-DNA complex with insights into AOA1 neurodegenerative disease.
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