Journal article icon

Journal article

Structure of an aprataxin-DNA complex with insights into AOA1 neurodegenerative disease.

Abstract:

DNA ligases finalize DNA replication and repair through DNA nick-sealing reactions that can abort to generate cytotoxic 5'-adenylation DNA damage. Aprataxin (Aptx) catalyzes direct reversal of 5'-adenylate adducts to protect genome integrity. Here the structure of a Schizosaccharomyces pombe Aptx-DNA-AMP-Zn(2+) complex reveals active site and DNA interaction clefts formed by fusing a histidine triad (HIT) nucleotide hydrolase with a DNA minor groove-binding C(2)HE zinc finger (Znf). An Aptx h...

Expand abstract

Actions


Access Document


Publisher copy:
10.1038/nsmb.2146

Authors


Expand authors...
Journal:
Nature structural and molecular biology
Volume:
18
Issue:
11
Pages:
1189-1195
Publication date:
2011-11-05
DOI:
EISSN:
1545-9985
ISSN:
1545-9993
URN:
uuid:4c6afcd9-6ac9-4183-9881-bdd9f63a4c85
Source identifiers:
376194
Local pid:
pubs:376194

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP