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Atrial sources of reactive oxygen species vary with the duration and substrate of atrial fibrillation: implications for the antiarrhythmic effect of statins.

Abstract:

BACKGROUND: An altered nitric oxide-redox balance has been implicated in the pathogenesis of atrial fibrillation (AF). Statins inhibit NOX2-NADPH oxidases and prevent postoperative AF but are less effective in AF secondary prevention; the mechanisms underlying these findings are poorly understood. METHODS AND RESULTS: By using goat models of pacing-induced AF or of atrial structural remodeling secondary to atrioventricular block and right atrial samples from 130 patients undergoing cardiac su...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM
Jayaram, R More by this author
Antoniades, C More by this author
Verheule, S More by this author
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Journal:
Circulation
Volume:
124
Issue:
10
Pages:
1107-1117
Publication date:
2011-09-05
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
URN:
uuid:4c5846cb-adf2-4798-862c-485ee05626bc
Source identifiers:
177376
Local pid:
pubs:177376

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