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Shear stress-induced shedding of soluble intercellular adhesion molecule-1 from saphenous vein endothelium.

Abstract:

Within 6 h, shear stress upregulated intercellular adhesion molecule-1 (ICAM-1) (two- to four-fold, P<0.001) and induced matrix metalloproteinase-2 (MMP-2) in cultured human saphenous vein endothelial cells. By 8 h endothelial ICAM-1 levels returned to baseline, with concomitant increase in soluble ICAM-1 (sICAM-1) (P<0.001) and MMP-9 had been induced. Inclusion of a hydroxamate metalloproteinase inhibitor partially reversed the effects on ICAM-1 and sICAM-1 at 8 h, whereas TIMP-1, -2 o...

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
FEBS letters
Volume:
564
Issue:
1-2
Pages:
161-165
Publication date:
2004-04-01
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
Source identifiers:
227287
Language:
English
Keywords:
Pubs id:
pubs:227287
UUID:
uuid:4c4ce0d8-0541-4be4-a506-901a87729f8a
Local pid:
pubs:227287
Deposit date:
2012-12-19

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