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Enhancement of humoral and cellular immunity with an anti-glucocorticoid-induced tumour necrosis factor receptor monoclonal antibody.

Abstract:

Adjuvants, including antibodies to tumour necrosis factor receptor superfamily members, augment immune responses. One member of this family, glucocorticoid-induced tumour necrosis factor receptor (GITR), is expressed at low levels on naive/resting T cells, B cells and macrophages, but at higher levels on T regulatory cells. The aim of this study was to determine the ability of a rat anti-mouse GITR monoclonal antibody, 2F8, to stimulate murine humoral and cellular immunity in a prime boost mo...

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Publication status:
Published

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Authors


Slavonic, M More by this author
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Journal:
Immunology
Volume:
130
Issue:
2
Pages:
231-242
Publication date:
2010-06-05
DOI:
EISSN:
1365-2567
ISSN:
0019-2805
URN:
uuid:4c46d3b1-5b9e-437b-a78f-31c4f490bc5f
Source identifiers:
50301
Local pid:
pubs:50301

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