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Renal cell carcinoma: Translational aspects of metabolism and therapeutic consequences

Abstract:

The heterogeneity of renal cell carcinoma (RCC) poses a challenge for designing clinically applicable diagnostic and screening investigations, predictive and prognostic biomarkers, and targeted molecular therapies. Hereditary RCC syndromes harbor specific driver gene mutations, and their discoveries have provided unequivocal insight into the pathogenomic landscape of RCCs. These observed genetic aberrations correspond to a diverse range of dysplastic metabolic processes, including mutations i...

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Publisher copy:
10.1038/ki.2013.245

Authors


Journal:
Kidney International
Volume:
84
Issue:
4
Pages:
667-681
Publication date:
2013-10-01
DOI:
EISSN:
1523-1755
ISSN:
0085-2538
Source identifiers:
435843
Language:
English
Keywords:
Pubs id:
pubs:435843
UUID:
uuid:4c3e87d1-b7f1-4710-8ca3-2f619e66f853
Local pid:
pubs:435843
Deposit date:
2013-11-16

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