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Biodistribution and persistence of an MVA-vectored candidate HIV vaccine in SIV-infected rhesus macaques and SCID mice.

Abstract:

Recombinant modified vaccinia virus Ankara (MVA) is together with a few other attenuated viral vectors on the forefront of human immunodeficiency virus type 1 (HIV-1) vaccine development. As such, MVA-vectored vaccines are likely to be administered into immunocompromized individuals. Here, we demonstrated in a good laboratory practice study safety and biological clearance of candidate HIV-1 vaccine MVA.HIVA in simian immunodeficiency virus (SIV)-infected rhesus macaques and mice with a severe...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Dennis, MJ More by this author
Sharpe, SA More by this author
Powell, LA More by this author
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Journal:
Vaccine
Volume:
23
Issue:
12
Pages:
1507-1514
Publication date:
2005-02-05
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
URN:
uuid:4c2b6d90-aa69-4ee6-8d6a-07970ae6936a
Source identifiers:
32967
Local pid:
pubs:32967

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