Journal article icon

Journal article

Exacerbation of endothelial dysfunction during the progression of diabetes: role of oxidative stress.

Abstract:

To test the deterioration of endothelial function during the progression of diabetes, shear stress-induced dilation (SSID; 10, 20, and 40 dyn/cm(2)) was determined in isolated mesenteric arteries (80-120 μm in diameter) of 6-wk (6W), 3-mo (3M), and 9-mo (9M)-old male db/db mice and their wild-type (WT) controls. Nitric oxide (NO)-mediated SSID was comparable in 6W WT and db/db mice, but the dilation was significantly reduced in 3M db/db mice and declined further in 9M db/db mice. Vascular sup...

Expand abstract

Actions


Access Document


Publisher copy:
10.1152/ajpregu.00699.2011

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Expand authors...
Journal:
American journal of physiology. Regulatory, integrative and comparative physiology
Volume:
302
Issue:
6
Pages:
R674-R681
Publication date:
2012-03-05
DOI:
EISSN:
1522-1490
ISSN:
0363-6119
URN:
uuid:4c26eb3e-00bb-40dd-aed6-b87cd0d26a2c
Source identifiers:
245835
Local pid:
pubs:245835

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP