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Signature-tagged mutagenesis: barcoding mutants for genome-wide screens.

Abstract:

DNA signature tags (molecular barcodes) facilitate functional screens by identifying mutants in mixed populations that have a reduced or increased adaptation to a particular environment. Many innovative adaptations and refinements in the technology have been described since its original use with Salmonella; they have yielded a wealth of information on a broad range of biological processes--mainly in bacteria, but also in yeast and other fungi, viruses, parasites and, most recently, in mammali...

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Publisher copy:
10.1038/nrg1984

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Journal:
Nature reviews. Genetics
Volume:
7
Issue:
12
Pages:
929-939
Publication date:
2006-12-05
DOI:
EISSN:
1471-0064
ISSN:
1471-0056
URN:
uuid:4c246f71-9331-4ebe-942c-c5f6394c8ad6
Source identifiers:
249491
Local pid:
pubs:249491

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