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Journal article

Nigral transplants reinnervating the dopamine-depleted neostriatum can sustain intracranial self-stimulation.

Abstract:
Transplants of embryonic substantia nigra reinnervated the striatum and were able to sustain intracranial self-stimulation in rats with brain lesions induced by 6-hydroxydopamine. Dopaminergic drugs and alterations in current intensity produced typical changes in response rates. Animals with electrodes implanted into cortical grafts or into the denervated striatum failed to exhibit self-stimulation. These findings suggest that transplanted dopamine neurons convey specific, temporally organized information axonally to the striatum.
Publication status:
Published

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Publisher copy:
10.1126/science.6849143

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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Role:
Author
Journal:
Science (New York, N.Y.)
Volume:
219
Issue:
4583
Pages:
416-419
Publication date:
1983-01-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:4c23df38-21f5-480d-be37-23e65c482ef5
Source identifiers:
25013
Local pid:
pubs:25013

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