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Structures of respiratory syncytial virus nucleocapsid protein from two crystal forms: Details of potential packing interactions in the native helical form

Abstract:

Respiratory syncytial virus (RSV) is a frequent cause of respiratory illness in infants, but there is currently no vaccine nor effective drug treatment against this virus. The RSV RNA genome is encapsidated and protected by a nucleocapsid protein; this RNA-nucleocapsid complex serves as a template for viral replication. Interest in the nucleocapsid protein has increased owing to its recent identification as the target site for novel anti-RSV compounds. The crystal structure of human respirato...

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Publisher copy:
10.1107/S1744309111029228

Authors


El Omari, K More by this author
Dhaliwal, B More by this author
Abrescia, NGA More by this author
Lockyer, M More by this author
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Journal:
Acta Crystallographica Section F: Structural Biology and Crystallization Communications
Volume:
67
Issue:
10
Pages:
1179-1183
Publication date:
2011-10-05
DOI:
EISSN:
1744-3091
URN:
uuid:4c223c98-349e-4a62-81ee-71c9ca9af814
Source identifiers:
245925
Local pid:
pubs:245925

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