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Gtdap-1 promotes autophagy and is required for planarian remodeling during regeneration and starvation.

Abstract:

Remodeling is an integral component of tissue homeostasis and regeneration. In planarians, these processes occur constantly in a simple tractable model organism as part of the animal's normal life history. Here, we have studied the gene Gtdap-1, the planarian ortholog of human death-associated protein-1 or DAP-1. DAP-1, together with DAP-kinase, has been identified as a positive mediator of programmed cell death induced by gamma-IFN in HeLa cells. Although the function of DAP-kinase is well c...

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Publisher copy:
10.1073/pnas.0703588104

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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Role:
Author
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
104
Issue:
33
Pages:
13373-13378
Publication date:
2007-08-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:4c1bcff2-e0c3-4e9d-8037-3fd213de8156
Source identifiers:
375955
Local pid:
pubs:375955

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