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Journal article

Delivery of large genomic DNA inserts >100 kb using HSV-1 amplicons.

Abstract:

The principal aim of gene therapy for recessive genetic diseases is to supplement the loss of function of an endogenous gene. For the treatment of many diseases regulation of transgene expression at physiological levels, expression of multiple splice variants, and correct tissue specificity are of utmost importance for effective therapy. We therefore believe the use of a complete genomic locus, in which the native promoter and regulatory regions drive and control expression, is an elegant and...

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Publication status:
Published

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Publisher copy:
10.2174/156652306777592054

Authors


Hibbitt, OC More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
Current gene therapy
Volume:
6
Issue:
3
Pages:
325-336
Publication date:
2006-06-05
DOI:
EISSN:
1875-5631
ISSN:
1566-5232
URN:
uuid:4c1b6239-92af-4e0e-a67d-238c6b9ee29f
Source identifiers:
113867
Local pid:
pubs:113867
Language:
English
Keywords:

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