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Thesis

Asymmetric synthesis of heterocycles via cation-directed cyclizations and rearrangements

Abstract:

The aim of this project was to utilize chiral cation-directed catalysis in the asymmetric synthesis of novel hererocycles. This goal was initially realized by the synthesis of azaindolines in high yields and enantioselectivities (Chapter 2).

Extension of this methodology to substrates bearing two stereogenic centres was successful, although control over both diastereoselectivity and enantioselectivity in this process was modest.

Finally the synthesis of heterocycles utilizi...

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Institution:
University of Oxford
Research group:
Martin D Smith
Oxford college:
Linacre College
Department:
Mathematical,Physical & Life Sciences Division - Chemistry - Organic Chemistry

Contributors

Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:4c0cf06c-d461-42a4-b4d8-a2a2bd961435
Local pid:
ora:10751

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