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Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity

Abstract:

Antimalarial compounds with dual therapeutic and transmission-blocking activity are desired as high-value partners for combination therapies. Here, we report the identification and characterization of hexahydroquinolines (HHQs) that show low nanomolar potency against both pathogenic and transmissible intra-erythrocytic forms of the malaria parasite Plasmodium falciparum. This activity translates into potent transmission-blocking potential, as shown by in vitro male gamete formation assays and...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/s41564-017-0007-4

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ORCID:
0000-0002-9141-2347
Lucantoni, L More by this author
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ORCID:
0000-0002-5097-2137
Combrinck, JM More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Tropical Medicine
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Microbiology Journal website
Volume:
2
Pages:
1403-1414
Publication date:
2017-08-14
Acceptance date:
2017-07-11
DOI:
ISSN:
2058-5276
Pubs id:
pubs:724243
URN:
uri:4c03a3f7-9309-42f4-b53f-ca2abcd97a7a
UUID:
uuid:4c03a3f7-9309-42f4-b53f-ca2abcd97a7a
Local pid:
pubs:724243
Language:
English
Keywords:

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