Blimp1 regulates development of the posterior forelimb, caudal pharyngeal arches, heart and sensory vibrissae in mice.

Journal article

The zinc-finger transcriptional repressor Blimp1 (Prdm1) controls gene expression patterns during differentiation of B lymphocytes and regulates epigenetic changes required for specification of primordial germ cells. Blimp1 is dynamically expressed at diverse tissue sites in the developing mouse embryo, but its functional role remains unknown because Blimp1 mutant embryos arrest at E10.5 due to placental insufficiency. To explore Blimp1 activities at later stages in the embryo proper, here we...

Expand abstract

Authors: Robertson, E; Charatsi, I; Joyner, C; Koonce, C; Morgan, M

• Publication status: Published
• Journal: Development (Cambridge, England)
• Volume: 134
• Issue: 24
• Pages: 4335-4345
• Publication date: 2007-12-01
• DOI: 10.1242/dev.012047
• EISSN: 1477-9129
• ISSN: 0950-1991
• Language: English
• Keywords: Multipotent Stem Cells; Fetal Heart; Vibrissae; Embryonic Stem Cells; Mice; Recombinant Proteins; Mice, Transgenic; Animals; Gene Expression Regulation, Developmental; Forelimb; Branchial Region; Heterozygote; Mice, Mutant Strains; Green Fluorescent Proteins; Genes, Reporter; Embryonic Development; Base Sequence; Phenotype; DNA Primers; Transcription Factors; Organ Specificity; Repressor Proteins