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Journal article

Tetramer-guided analysis of TCR beta-chain usage reveals a large repertoire of melan-A-specific CD8+ T cells in melanoma patients.

Abstract:

The assessment of the TCR repertoire expressed by tumor-specific CD8+ T lymphocytes has been hampered to date by the difficulty of targeting the analysis to lymphocytes directed against a single epitope. In the present study we have used fluorescent A2/Melan-A tetramers in conjunction with anti-CD8 and anti-TCR beta-chain variable (BV) mAbs to analyze by flow cytometry the BV segment usage by Melan-A-specific CD8+ T cells in tumor-infiltrated lymph nodes (TILN) and tumor-infiltrating lymphocy...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.165.1.533

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Journal:
Journal of Immunology
Volume:
165
Issue:
1
Pages:
533-538
Publication date:
2000-07-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
31701

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