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Journal article

Overexpression of rapsyn in rat muscle increases acetylcholine receptor levels in chronic experimental autoimmune myasthenia gravis.

Abstract:

The primary autoantigen in myasthenia gravis, the acetylcholine receptor (AChR), is clustered and anchored in the postsynaptic membrane of the neuromuscular junction by rapsyn. Previously, we found that overexpression of rapsyn by cDNA transfection protects AChRs in rat muscles from antibody-mediated loss in passive transfer experimental autoimmune myasthenia gravis (EAMG). Here, we determined whether rapsyn overexpression can reduce or even reverse AChR loss in muscles that are already damag...

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Publication status:
Published

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Publisher copy:
10.2353/ajpath.2007.060676

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Journal:
American journal of pathology
Volume:
170
Issue:
2
Pages:
644-657
Publication date:
2007-02-01
DOI:
EISSN:
1525-2191
ISSN:
0002-9440
Source identifiers:
346316
Language:
English
Keywords:
Pubs id:
pubs:346316
UUID:
uuid:4bfb034b-163b-4d68-839e-7af1a4e4542c
Local pid:
pubs:346316
Deposit date:
2013-11-16

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