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Journal article

Common variants at 30 loci contribute to polygenic dyslipidemia.

Abstract:

Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglyceride levels are risk factors for cardiovascular disease. To dissect the polygenic basis of these traits, we conducted genome-wide association screens in 19,840 individuals and replication in up to 20,623 individuals. We identified 30 distinct loci associated with lipoprotein concentrations (each with P < 5 x 10(-8)), including 11 loci that reached genome-wide significance for the first t...

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Publication status:
Published

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Publisher copy:
10.1038/ng.291

Authors


Kathiresan, S More by this author
Willer, CJ More by this author
Peloso, GM More by this author
Demissie, S More by this author
Musunuru, K More by this author
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Journal:
Nature genetics
Volume:
41
Issue:
1
Pages:
56-65
Publication date:
2009-01-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:4bf7b381-5e10-41d4-99a6-b6501ceded24
Source identifiers:
41005
Local pid:
pubs:41005

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