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Glutathione-S-transferase FosA6 of klebsiella pneumoniae origin conferring fosfomycin resistance in ESBL-producing Escherichia coli

Abstract:

Objectives: The objectives of this study were to elucidate the genetic context of a novel plasmid-mediated fosA variant, fosA6, conferring fosfomycin resistance and to characterize the kinetic properties of FosA6.
Methods: The genome of fosfomycin-resistant Escherichia coli strain YD786 was sequenced. Homologues of FosA6 were identified through BLAST searches. FosA6 and FosAST258 were purified and characterized using a steady-state kinetic approach. ... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/jac/dkw177

Authors


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Role:
Author
ORCID:
0000-0001-7726-0765
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
ORCID:
0000-0002-4508-7969
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Name:
NCATS NIH HHS
Grant:
UL1 TR001863
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Name:
NIAID NIH HHS
Grant:
R01 AI104895
R21 AI123747
R21 AI107302
Publisher:
Oxford University Press
Journal:
Journal of Antimicrobial Chemotherapy More from this journal
Volume:
71
Issue:
9
Pages:
2460-2465
Publication date:
2016-06-03
Acceptance date:
2016-04-17
DOI:
EISSN:
1460-2091
ISSN:
0305-7453
Pmid:
27261267
Language:
English
Keywords:
Pubs id:
pubs:628167
UUID:
uuid:4bf1a063-d6c8-45ab-b47a-fe97108a4e59
Local pid:
pubs:628167
Source identifiers:
628167
Deposit date:
2019-03-04

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