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Toll-like receptor 7 protects from atherosclerosis by constraining inflammatory macrophage activation

Abstract:

Background: Toll-like receptors (TLRs) have long been considered to be major culprits in the development of atherosclerosis, contributing both to its progression and clinical complications. However, evidence for most TLRs beyond TLR2 and TLR4 is lacking. Methods and Results: We used experimental mouse models, human atheroma cultures, and well-established human biobanks to investigate the role of TLR7 in atherosclerosis. We report the unexpected finding that TLR7, a receptor recognizing self-n...

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Journal:
Circulation
Volume:
126
Issue:
8
Pages:
952-962
Publication date:
2012-08-21
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
URN:
uuid:4bdd5bce-f33b-4198-9750-ef35c246775b
Source identifiers:
351114
Local pid:
pubs:351114

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