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Journal article

The role of renal chloride channel mutations in kidney stone disease and nephrocalcinosis.

Abstract:

Recent advances in molecular biology have characterised a new class of chloride channels (CLCs) that are referred to as voltage-gated CLCs. To date nine such voltage-gated CLCs (CLC-1 to CLC-7, CLC-Ka and CLC-Kb, which are encoded by the genes CLCN1 to CLCN7, CLC-Ka and CLC-Kb, respectively) have been identified in mammals. Mutations in two of these, CLC-5 and CLC-Kb, have been defined in the hypercalciuric nephrolithiasis disorders of Dent's disease and a form of Bartter's syndrome, respecti...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Journal:
Current opinion in nephrology and hypertension
Volume:
7
Issue:
4
Pages:
385-388
Publication date:
1998-07-05
DOI:
EISSN:
1473-6543
ISSN:
1062-4821
URN:
uuid:4bc9a6db-e2c8-4f6f-b08e-cad99c5e9de4
Source identifiers:
27822
Local pid:
pubs:27822

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