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Faster, higher, stronger? Evidence for formulation and efficacy for ibuprofen in acute pain.

Abstract:

A Cochrane review of ibuprofen in acute pain suggested that rapidly absorbed formulations of salts, or features to speed absorption, provided better analgesia than standard ibuprofen as the free acid. We examined several lines of evidence to investigate what benefit derived from fast-acting formulations. A systematic review of the kinetics of oral ibuprofen (30 studies, 1015 subjects) showed that median maximum plasma concentrations of fast-acting formulations occurred before 50 min (29-35 mi...

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Publication status:
Published

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Publisher copy:
10.1016/j.pain.2013.08.013

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Straube, S More by this author
Ireson-Paine, J More by this author
Wiffen, PJ More by this author
Journal:
Pain
Volume:
155
Issue:
1
Pages:
14-21
Publication date:
2014-01-05
DOI:
EISSN:
1872-6623
ISSN:
0304-3959
URN:
uuid:4bc12604-2cd1-4651-b6dc-640fe8f56ec0
Source identifiers:
420859
Local pid:
pubs:420859

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