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Role of macrophages in the generation of T helper cells. IV. Nature of genetically related factor derived from macrophages incubated with soluble antigens.

Abstract:

Macrophages incubated with soluble antigens for 1-4 days release factors capable of inducing T helper cells. The nature and some of the properties of this genetically related macrophage factor (GRF) were investigated. By use of immunoadsorbents, GRF was shown to contain I region-coded products (Ia antigens) linked to a small antigenic fragment. The genes coding for the Ia antigens detectable in GRF lie in the I region of the H-2 complex. GRF does not react with anti-immunoglobulin, anti-C3 or...

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Publication status:
Published

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Publisher copy:
10.1002/eji.1830060512

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
European journal of immunology
Volume:
6
Issue:
5
Pages:
365-372
Publication date:
1976-05-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:4bbd81fc-7849-48b2-ba0f-074615a6a9ae
Source identifiers:
481860
Local pid:
pubs:481860

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